The Proteomics and Metabolomics Analysis for Screening the Molecular Targets of Action of β-Eudesmol in Cholangiocarcinoma.

Kanawut KotawongWanna ChajaroenkulSittiruk RoytrakulNarumon PhaonakropKesara Na-Bangchang

Published in: Asian Pacific journal of cancer prevention : APJCP (2021)

Possible molecular targets of action of β-eudesmol against CL-6 for cell apoptosis induction were TNFRSf6, cytochrome C, BAX3, DHCR24, CD29, and ATP. On the other hand, possible targets for cell cycle arrest induction were CDKN2B, MLF1, TFDP2, CDK11-p110, and nicotinamide.

Keyphrases

cell cycle arrest
mass spectrometry
cell death
pi k akt
cell proliferation
single molecule
cell cycle
signaling pathway
induced apoptosis
oxidative stress
data analysis