Novel drug delivery systems of β2 adrenoreceptor agonists to suppress SNCA gene expression and mitochondrial oxidative stress in Parkinson's disease management.

Piyong SolaPraveen Thaggikuppe Krishnamurthy Pavan Kumar Chintamaneni Sai Kiran S S PindiproluMamta Kumari

Published in: Expert opinion on drug delivery (2020)

Brain targeted delivery of β2AR agonists via various nano delivery systems will significantly downregulate SNCA gene expression in PD and also overcomes peripheral side effects of β2AR agonists.

Keyphrases

gene expression
oxidative stress
dna methylation
dna damage
white matter
ischemia reperfusion injury
diabetic rats
induced apoptosis
multiple sclerosis
cerebral ischemia
brain injury