Neuropilin-1 promotes mitochondrial structural repair and functional recovery in rats with cerebral ischemia.

Ting GuoManli ChenJi LiuZengyu WeiJinjin YuanWenwen WuZhiyun WuYongxing LaiZijun ZhaoHongbin ChenXin-Hong Jiang

Published in: Journal of translational medicine (2023)

NRP-1 can produce neuroprotective effects against I/R injury to the brain by activating the Wnt/β-catenin signaling pathway and promoting mitochondrial structural repair and functional recovery, which may serve as a promising candidate target in treating ischemic stroke.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
blood brain barrier
oxidative stress
brain injury
stem cells
cell proliferation
signaling pathway
atrial fibrillation
white matter
resting state
functional connectivity