ent -Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice.

Aaron GochmanTri Q DoKyungsoo KimJacob A SchwarzMadelaine P ThorpeDaniel J BlackwellAbigail N SmithWendell S AkersRazvan L CorneaDerek R LaverJeffrey N JohnstonBjörn C Knollmann

Published in: bioRxiv : the preprint server for biology (2023)

The cardiac ryanodine receptor (RyR2) is an untapped target in the stagnant field of antiarrhythmic drug development. We have confirmed RyR2 as an antiarrhythmic target in a mouse model of sudden cardiac death and shown the therapeutic efficacy of a second enantiomeric natural product.

Keyphrases

mouse model
catheter ablation
left ventricular
heart failure
high fat diet induced
adipose tissue
metabolic syndrome
mass spectrometry
capillary electrophoresis
insulin resistance