Single-Cell RNA Sequencing Unveils the Clonal and Transcriptional Landscape of Cutaneous T-Cell Lymphomas.

Alyxzandria M GaydosikConnor J StonesiferAlexandra E KhaleelLarisa J GeskinPatrizia Fuschiotti

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our analysis unveils new insights into mycosis fungoides/Sézary syndrome pathogenesis by providing an unprecedented report of the transcriptional profile of malignant T-cell clones in the skin and blood of individual patients and offers novel prospective targets for personalized therapy.

Keyphrases

single cell
end stage renal disease
rna seq
gene expression
newly diagnosed
chronic kidney disease
ejection fraction
transcription factor
peritoneal dialysis
prognostic factors
stem cells
mesenchymal stem cells
wound healing
patient reported outcomes
patient reported
chemotherapy induced