The COX-2-PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas.

Jie WeiJinyu ZhangDingzhi WangBo CenJessica D LangRaymond N DuBois

Published in: Cancer prevention research (Philadelphia, Pa.) (2022)

These findings provide a potential explanation underlying the chemopreventive effect of NSAIDs on reducing colorectal cancer incidence during premalignancy and provide a rationale for developing EP4 antagonists for colorectal cancer prevention and treatment. Simply targeting PGE2 signaling alone may be efficacious in colorectal cancer prevention and treatment, avoiding side effects associated with NSAIDs.

Keyphrases

clinical trial
risk factors
combination therapy
drug delivery