EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas.

Tanner J DuCote Xiulong Song Kassandra J Naughton Fan Chen Daniel R Plaugher Avery R Childress Abigail R Gellert Erika M Skaggs Xufeng Qu Jinze Liu Jinpeng Liu Fei Li Kwok-Kin Wong Christine Fillmore Brainson

Published in: Cancer research communications (2024)

The data described here show that inhibition of the epigenetic enzyme EZH2 allows derepression of multiple immunogenicity factors in LSCC, and that EZH2 inhibition alters myeloid cells in vivo. These data support clinical translation of this combination therapy for treatment of this deadly tumor type.

Keyphrases

squamous cell
long non coding rna
electronic health record
long noncoding rna
induced apoptosis
big data
dna methylation
acute myeloid leukemia
high grade
cell cycle arrest
data analysis
artificial intelligence
deep learning
smoking cessation