Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway.
Lu WangJing-Wen YangLi-Ting LinJin HuangXue-Rui WangXin-Tong SuYan CaoMarc FisherCun-Zhi LiuPublished in: Oxidative medicine and cellular longevity (2020)
Taken together, these findings provide evidence that acupuncture attenuates cognitive impairment associated with inflammation through inhibition of the miR-93-mediated TLR4/MyD88/NF-κB signaling pathway in experimental VD. Acupuncture serves as a promising alternative therapy and may be an underlying TLR4 inhibitor for the treatment of VD.
Keyphrases
- signaling pathway
- toll like receptor
- inflammatory response
- cognitive impairment
- pi k akt
- nuclear factor
- cell proliferation
- oxidative stress
- long non coding rna
- lps induced
- immune response
- induced apoptosis
- epithelial mesenchymal transition
- long noncoding rna
- mild cognitive impairment
- stem cells
- neuropathic pain
- bone marrow
- spinal cord
- endoplasmic reticulum stress
- spinal cord injury