β-actin mediated H3K27ac changes demonstrate the link between compartment switching and enhancer-dependent transcriptional regulation.

Syed Raza MahmoodNadine Hosny El SaidKristin C GunsalusPiergiorgio Percipalle

Published in: Genome biology (2023)

We demonstrate that enhancer-dependent transcriptional regulation plays a crucial role in driving gene expression changes observed upon compartment-switching. Our results also reveal a novel function of nuclear β-actin in regulating enhancer function by influencing H3K27 acetylation levels.

Keyphrases

gene expression
binding protein
transcription factor
single cell