Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation and cytokine responses in COVID-19.

Shelly J RobertsonOlivia BedardKristin L McNallyMatthew LewisChad ClancyCarl ShaiaRebecca M BroeckelAbhilash I ChiramelGail L SturdevantElvira ForteChristoph PreussCandice N BakerJeffrey HarderCatherine BruntonSteven MungerDaniel E SturdevantCraig MartensSteven M HollandNadia A RosenthalSonja M Best

Published in: bioRxiv : the preprint server for biology (2022)

Genetically diverse mice display a broad spectrum of clinically relevant responses to SARS-CoV-2 infection, reflecting variability in COVID-19 disease.

Keyphrases

coronavirus disease
respiratory syndrome coronavirus
sars cov
mouse model
high fat diet induced
type diabetes
metabolic syndrome
insulin resistance
wild type