Mitochondrial ribosomal small subunit (MRPS) MRPS23 protein-protein interaction reveals phosphorylation by CDK11-p58 affecting cell proliferation and knockdown of MRPS23 sensitizes breast cancer cells to CDK1 inhibitors.

Revathi Paramasivam OviyaKrishna Priya ThangaretnamBalaji RamachandranPriya RamanathanSubramani JayaveluGopisetty GopalThangarajan Rajkumar

Published in: Molecular biology reports (2022)

In conclusion, phosphorylation of MRPS23 by mitotic kinases might potentially be involved in the proliferation of breast cancer cells. Furthermore, MRPS23 can be targeted for sensitizing the breast cancer cells to CDK1 inhibitors.

Keyphrases

breast cancer cells
cell cycle
cell proliferation
protein protein
protein kinase
small molecule
signaling pathway
cancer therapy