Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting.
Marco VentinGiulia CattaneoShahrzad AryaJingyu JiaMaria Chiara GelmiYi SunLuke MaggsBruce R KsanderRobert M VerdijkGenevieve Marie BolandRussell William JenkinsRizwan HaqMartine J JagerXinhui WangSandra W RyeomCristina R FerronePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
These studies support a phase I clinical trial with iCas9.B7-H3 CAR T cells to treat patients with metastatic UM.