Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation.

Carmen De MiguelRandee SedakaMalgorzata KasztanJeremie M LeverMichelle SonnenbergerAndrew AbadChunhua JinPamela K CarminesDavid M Pollock Jennifer S Pollock

Published in: Acta physiologica (Oxford, England) (2018)

TUDCA protects against the development of glomerular and proximal tubular damage, decreases renal cell death and inflammation in the renal cortex in rats with ETB receptor dysfunction on a chronic high salt diet. These results highlight the potential use of TUDCA as a preventive tool against chronic high salt induced renal damage.

Keyphrases

oxidative stress
high glucose
diabetic rats
cell death
drug induced
functional connectivity
climate change
signaling pathway