Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.

Santiago Martínez-LumbrerasEwelina M KrysztofinskaArjun ThapaliyaAlessandro SpilotrosDijana Matak-VinkovicEnrico SalvadoriPeristera RobotiYvonne NyathiJanina H MuenchMaxie M RoesslerDmitri I SvergunStephen HighRivka Leah Isaacson

Published in: BMC biology (2018)

Our results provide novel insights into the structural complexity of SGTA and provide a new basis for mechanistic studies of substrate binding and release at the C-terminal region.

Keyphrases

quality control
transcription factor
heat shock protein
amino acid
structural basis
heat shock
oxidative stress
binding protein