Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis.
Narjes Nasiri-AnsariChrysa NikolopoulouKaterina PapoutsiIoannis KyrouChristos S MantzorosGeorgios KyriakopoulosAntonios ChatzigeorgiouVassiliki KalotychouManpal S RandevaKamaljit ChathaKonstantinos KontzoglouGregory KaltsasDonatella Delle CaveHarpal S RandevaEva KassiPublished in: International journal of molecular sciences (2021)
These novel findings indicate that empagliflozin treatment for five weeks attenuates NAFLD progression in ApoE(-/-) mice by promoting autophagy, reducing ER stress and inhibiting hepatic apoptosis.