Sevoflurane protects rat brain endothelial barrier structure and function after hypoxia-reoxygenation injury.

Tanja RestinMarie-Elisabeth KajdiMartin SchläpferBirgit Roth Z'graggenChrista BooyClaudia DumreseBeatrice Beck-Schimmer

Published in: PloS one (2017)

In H/R-induced rat brain endothelial cell injury sevoflurane maintains endothelial barrier function through downregulation of VEGF, which is a key player not only in mediating injury, but also with regard to the protective effect of sevoflurane.

Keyphrases

endothelial cells
high glucose
vascular endothelial growth factor
cell proliferation
signaling pathway
oxidative stress