Penetrance of male breast cancer susceptibility genes: a systematic review.

Reem S ChamseddineCathy WangKanhua YinJin WangPreeti SinghJingan ZhouMark E RobsonDanielle BraunKevin S Hughes

Published in: Breast cancer research and treatment (2021)

This work supports the conclusion that pathogenic variants in ATM, BRCA2, CHEK2 c.1100delC, and PALB2 increase the risk of MBC, whereas pathogenic variants in BRCA1 may not be associated with increased MBC risk.

Keyphrases

breast cancer risk
copy number
genome wide
dna damage
dna repair
dna methylation
gene expression
genome wide identification
transcription factor