Potential Value of Identifying Type 2 Diabetes Subgroups for Guiding Intensive Treatment: A Comparison of Novel Data-Driven Clustering With Risk-Driven Subgroups.
Xinyu LiAnoukh van GiessenJames AltunkayaRoderick C SliekerJoline Wilhelma Johanna BeulensLeendert M 't HartEwan R PearsonPetra J M EldersTalitha L FeenstraShelby D ReedPublished in: Diabetes care (2023)
Risk-driven subgroups better discriminated prognosis. Both stratification methods supported stratified treatment intensification, with the risk-driven subgroups being somewhat better in identifying individuals with the most potential to benefit from intensive treatment. Irrespective of stratification approach, better cholesterol and weight control showed substantial potential for health gains.