Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease.
Matt D WorssamJordi LambertSebnem OcJames Ck TaylorAnnabel L TaylorLina DobnikarJoel ChappellJennifer L HarmanNichola L FiggAlison FiniganKirsty FooteAnna K UrygaMartin R BennettMikhail SpivakovHelle F JørgensenPublished in: Cardiovascular research (2022)
Our data suggest that activation of proliferation at low frequency is a general, cell-intrinsic feature of VSMCs. We show that rare VSMCs in healthy arteries display VSMC phenotypic switching akin to that observed in pathological vessel remodelling and that this is a conserved feature of mouse and human healthy arteries. The increased proliferation of modulated VSMCs from healthy arteries suggests that these cells respond more readily to disease-inducing cues and could drive oligoclonal VSMC expansion.
Keyphrases
- smooth muscle
- cardiovascular disease
- single cell
- vascular smooth muscle cells
- machine learning
- signaling pathway
- cell therapy
- endothelial cells
- induced apoptosis
- deep learning
- blood flow
- stem cells
- electronic health record
- mesenchymal stem cells
- cell death
- metabolic syndrome
- coronary artery disease
- big data
- angiotensin ii
- bone marrow
- neural network