Comparison of ultrafiltration and microdialysis for ceftriaxone protein-binding determination.

Maria Sanz-CodinaSebastian G WichaBeatrix WulkersdorferValentin Al JalaliWisse Van OsMatthias G VossenMartin BauerEdith LacknerChristoph DornMarkus Zeitlinger

Published in: The Journal of antimicrobial chemotherapy (2022)

In vitro UF versus in vivo intravasal MD revealed significantly different PB, especially during the distribution phase. The method of PB determination could have an impact on the breakpoint determination and dose optimisation of antibiotics.

Keyphrases

solid phase extraction
molecularly imprinted
heavy metals
binding protein
molecular dynamics
single cell
risk assessment
transcription factor
amino acid
dna binding