Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury.
Yunhui DuYanru DuanJianli ZhaoCaihong LiuZhen ZhangJohn ZhangZhijun MengXiaoliang WangWayne Bond LauDina XieBernard L LopezTheodore A ChristopherErhe GaoWalter J KochHuirong LiuDemin LiuXin-Liang MaGuoqiang GuYajing WangPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Hypoadiponectinemia and dysregulation of APPL1-mediated epigenetic regulation are novel mechanisms leading to diabetes-induced suppression of vasculoprotective gene expression. Diabetes-induced pathological vascular remodeling may be prevented by interventions promoting APPL1 nuclear translocation and inhibiting HDAC2.