Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation.
Mengping JiaQinhan LiJieyu GuoWeihao ShiLei ZhuYijun HuangYongbo LiLi WangSiyu MaTao ZhuangXiao Qun WangQi PanXiangxiang WeiYue QinXiaobo LiJiayu JinXiuling ZhiJingdong TangQing JingShanqun LiLindi JiangLe-Feng QuElena OstoJianyi ZhangXinhong WangBo YuDan MengPublished in: Circulation research (2022)
These data identify BACH1 as a mechanosensor of hemodynamic stress and reveal that the BACH1-YAP transcriptional network is essential to vascular inflammation and atherogenesis. BACH1 shows potential as a novel therapeutic target in atherosclerosis.