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Development of a method for the determination of 8-iso-PGF2α in sheep and goat plasma using solid-phase microextraction and ultra-performance liquid chromatography/tandem mass spectrometry.

Gabriela Rodríguez PatiñoMiriam Aide Castillo RodríguezJacinto Efren Ramírez BribiescaPatricia Ramírez NogueraMaría Eugenia Gonsebatt BonaparteRaquel Lopez-Arellano
Published in: Rapid communications in mass spectrometry : RCM (2018)
The method developed is precise, accurate and reliable with low reagent consumption compared with conventional solid-phase extraction. The analysis time was decreased because, with the use of the microextraction plate, the step of the evaporation and reconstitution of the analyte was avoided. The method is applicable to quantify the plasma total levels (esterified + free) of 8-iso-PGF2α.
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