Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis.
Jennifer M SanMiguelElizabeth EudyMatthew A LobergKira A YoungJayna J MistryKristina D MujicaLogan S SchwartzTimothy M StearnsGrant A ChallenJennifer J TrowbridgePublished in: Cancer discovery (2022)
Through the identification and dissection of TNFα signaling as a key driver of murine Dnmt3a-mutant hematopoiesis, we report the discovery that clone size and production of specific mature blood cell types can be independently regulated. See related commentary by Niño and Pietras, p. 2724. This article is highlighted in the In This Issue feature, p. 2711.
Keyphrases
- stem cells
- dna methylation
- single cell
- rheumatoid arthritis
- wild type
- cell therapy
- small molecule
- high throughput
- machine learning
- physical activity
- body composition
- transcription factor
- hematopoietic stem cell
- deep learning
- gene expression
- metal organic framework
- bioinformatics analysis
- mesenchymal stem cells
- cell fate
- transition metal