Sildenafil and calcitonin gene-related peptide dilate intradural arteries: A 3T MR angiography study in healthy volunteers.

Casper Emil ChristensenFaisal Mohammad AminSamaira YounisUlrich LindbergPatrick de KoningEsben Thade PetersenOlaf Bjarne PaulsonHenrik Bo Wiberg LarssonMessoud Ashina

Published in: Cephalalgia : an international journal of headache (2018)

An important novel finding is that both sildenafil and calcitonin gene-related peptide dilate intradural arteries, supporting the notion that all known pharmacological migraine triggers dilate cephalic vessels. We suggest that intradural artery dilation is associated with headache induced by calcitonin gene-related peptide and sildenafil.

Keyphrases

pulmonary hypertension
genome wide
copy number
pulmonary arterial hypertension
genome wide identification
optical coherence tomography
magnetic resonance
dna methylation
drug induced
transcription factor