Combined effects of 17β-estradiol and exercise training on cardiac apoptosis in ovariectomized rats.
Yi-Yuan LinJwo-Sheng ChenXu-Bo WuWoei-Cherng ShyuRungchai ChaunchaiyakulXian-Li ZhaoChia-Hua KuoYu-Jung ChengAi-Lun YangShin-Da LeePublished in: PloS one (2018)
Combined E2 and exercise training exhibited a positive effect of protection on ovariectomy-induced cardiac apoptosis by enhancing ERβ-related survival pathways, which might provide a more effective therapeutic effect on cardiac protection in bilaterally oophorectomized or menopausal women than E2 treatment only.
Keyphrases
- left ventricular
- oxidative stress
- endoplasmic reticulum stress
- skeletal muscle
- cell death
- cell cycle arrest
- estrogen receptor
- diabetic rats
- polycystic ovary syndrome
- bone loss
- high glucose
- type diabetes
- heart failure
- drug induced
- adipose tissue
- insulin resistance
- endothelial cells
- combination therapy
- endoplasmic reticulum