Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd0 -CalB CLEA as a Biohybrid Catalyst.
Karl P J GustafsonTamás GörbeGonzalo de Gonzalo-CalvoNing YuanCynthia L SchreiberAndrey ShchukarevCheuk-Wai TaiIngmar PerssonXiaodong ZouJan E BäckvallPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross-linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.