The signature of liver cancer in immune cells DNA methylation.

Yonghong ZhangSophie PetropoulosJinhua LiuDavid CheishviliRudy ZhouSergiy DymovKang LiNing LiMoshe Szyf

Published in: Clinical epigenetics (2018)

The study reveals a broad signature of hepatocellular carcinoma in PBMC and T cells DNA methylation which discriminates early HCC stage from chronic hepatitis B and C and healthy controls, intensifies with progression of HCC, and is highly enriched in immune function-related genes such as PD-1, a current cancer immunotherapy target. These data also support the feasibility of using these profiles for early detection of HCC.

Keyphrases

dna methylation
genome wide
gene expression
hepatitis b virus
electronic health record
big data
copy number
machine learning
deep learning