Genome-Wide Polygenic Risk Score Predicts Incident Type 2 Diabetes in Women With History of Gestational Diabetes.
Jaewon ChoiHyunsuk LeeAlan KuangAlicia Huerta-ChagoyaDenise M ScholtensDaeho ChoiMinseok HanWilliam L LoweAlisa K ManningHak Chul JangKyong Soo ParkSoo Heon KwakPublished in: Diabetes care (2024)
In cohorts of GDM women with diverse ancestry, T2D PRS was significantly associated with future development of T2D. A significant but small improvement was observed in AUROC when T2D PRS was integrated into clinical risk models to predict incident T2D.