Monitoring of Busulphan Concentrations in Children Undergone Hematopoietic Stem Cell Transplantation: Unicentric Experience over 10 years.

Maura FaraciCarmine TinelliEdoardo LaninoStefano GiardinoMassimiliano LeoniMarta FerrettiElio CastagnolaMonica BrogliaAnnalisa De SilvestriDaniela Di MartinoAntonella Bartoli

Published in: European journal of drug metabolism and pharmacokinetics (2018)

We concluded that older age at HSCT, intravenous administration of busulphan, cumulative, and prescribed dose of busulphan are associated with higher AUC levels. The absence of significant correlations between toxic events, graft failure, and AUC suggests the efficacy of busulphan concentrations monitoring in our patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
young adults
prognostic factors
peritoneal dialysis
physical activity
high dose
middle aged
patient reported