Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E -Driven Papillary Thyroid Cancer Patients.

Theodora PappaSara AhmadiEllen MarquseeHannah L JohnsonMatthew A NehsNancy L ChoJustine A BarlettaJochen H LorchGerard M DohertyNeal I LindemanErik K AlexanderIñigo Landa

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Identification of additional PIK3/AKT/mTOR alterations in patients with BRAFV600E -mutant PTC provides important and actionable prognostic risk stratification. These data support genomic profiling of PTC tumors to inform prognosis and clinical strategy.

Keyphrases

papillary thyroid
lymph node metastasis
cell proliferation
signaling pathway
electronic health record
transcription factor
squamous cell carcinoma
single cell
bioinformatics analysis
genome wide
deep learning