High JAK2V617F variant allele frequency is associated with coronary artery but not aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms.

Camilla Nordheim SolliSandra Chamat-HedemandHanne ElmingAnh NgoLasse Kjaer Vibe SkovAnders Lindholm SørensenChristina EllervikHans Carl Carl HasselbalchNiels Eske Bruun

Published in: European journal of haematology (2023)

In patients with MPNs, there is a significant association between having a VAF in the upper quartile (>52%), and severe coronary atherosclerosis, defined as a CACS >400. The presence of AVC is not associated with VAF.

Keyphrases

aortic valve
coronary artery
transcatheter aortic valve replacement
acute lymphoblastic leukemia
aortic stenosis
pulmonary artery
transcatheter aortic valve implantation
aortic valve replacement
cardiovascular disease
early onset
coronary artery disease
heart failure
drug induced
pulmonary arterial hypertension