Novel multi-drugs incorporating hybrid-structured nanofibers enhance alkylating agent activity in malignant gliomas.

Shih-Jung LiuShun-Tai YangShu-Mei ChenYin-Chen HuangWei-Hwa LeeJui HoYin-Chun ChenYuan-Yun Tseng

Published in: Therapeutic advances in medical oncology (2019)

The results demonstrated that O6-BG potentiates the effects of interstitially transported BiCNU and TMZ. Therefore, O6-BG may be required for alkylating agents to offer maximum therapeutic benefits for the treatment of MGMT-expressing tumors. In addition, the HSNM-supported chemoprotective gene therapy enhanced chemotherapy tolerance and efficacy. It can, therefore, potentially provide an improved therapeutic alternative for MGs.

Keyphrases

gene therapy
radiation therapy
combination therapy
smoking cessation