ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer.

Chun-Lin LinXi TanMeizhen ChenMeena KusiChia-Nung HungChih-Wei ChouYa-Ting HsuChiou-Miin WangNameer KirmaChun-Liang ChenChing-Hung LinKate I LathropRichard ElledgeVirginia G KaklamaniKohzoh MitsuyaTim Hui-Ming Huang

Published in: BMC medical genomics (2020)

This study demonstrates a new approach for identifying tumorigenic drivers from genomic regions highly susceptible to ERα-related chromothripsis. We found a group of luminal breast tumors displaying 17q-related chromothripsis for which antipsychotics can be repurposed as treatment adjuncts.

Keyphrases

copy number
estrogen receptor
endoplasmic reticulum
genome wide
breast cancer cells
dna methylation
young adults
replacement therapy