Association of Whole Blood Tacrolimus Concentrations with Kidney Injury in Heart Transplantation Patients.

Maaike A Sikma Claudine C Hunault Johannes H Kirkels Marianne Christina Verhaar Jozef Kesecioglu Dylan W de Lange

Published in: European journal of drug metabolism and pharmacokinetics (2018)

Supratherapeutic whole-blood tacrolimus trough concentrations are independently associated with the development of AKI in adult heart transplantation patients. More stringent dosing of tacrolimus early after transplantation may be critical in preserving the kidney function.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
acute kidney injury
stem cells
patient reported outcomes
young adults