Sequencing of the MHC region defines HLA-DQA1 as the major genetic risk for seropositive rheumatoid arthritis in Han Chinese population.

Jianping GuoTao ZhangHongzhi CaoXiaowei LiHao LiangMengru LiuYundong ZouYuanwei ZhangYuxuan WangXiaolin SunFanlei HuYan DuXiaodong MoXu LiuYue YangHuanjie YangXinyu WuXuewu ZhangHuijue JiaHui JiangYong HouXin LiuYin SuMingrong ZhangHuanming YangJian WangLiangdan SunLiang LiuLeonid PadyukovLuhua LaiKazuhiko YamamotoXuejun ZhangLars KlareskogXun XuZhanguo Li

Published in: Annals of the rheumatic diseases (2019)

We provide the first evidence that HLA-DQα1:160D, instead of HLA-DRB1*0405, is the strongest and independent genetic risk for ACPA-positive RA in Han Chinese. Our study also illustrates the value of deep sequencing for fine-mapping disease risk variants in the MHC region.

Keyphrases

rheumatoid arthritis
copy number
genome wide
single cell
disease activity
high resolution
mass spectrometry
systemic sclerosis
idiopathic pulmonary fibrosis