Mitochondrial DNA copy number plays opposing roles in T-lymphocyte infiltration of colorectal cancer based on mismatch repair status: new directions for immunotherapy?
Mian ChenHuashan LiuWenfeng LiangPinzhu HuangFujin YeYebing CaiZhenxing LiangLi XiongLiang KangLiang HuangPublished in: British journal of cancer (2024)
Our study found a potential relationship between mtDNA-CN and CRC development that differs by MMR status, potentially providing a rationale for the use of mtDNA-CN as both a predictive biomarker and a therapeutic target for ICIs.