Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants.

Hunter B DeanRory A GreerShan-Zhong YangDaniel S ElstonThomas J BrettErik D RobersonYuhua Song

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Triggering receptor expressed on myeloid cells 2 (TREM2) multimerization could regulate TREM2 activation and function. D87-R76 salt bridges at the interface of TREM2 units drive the formation of stable TREM2 dimers and trimers. Alzheimer's disease (AD)-associated R47H and R98W variants disrupt the D87-R76 salt bridge. The AD-associated D87N variant leads to complete loss of the D87-R76 salt bridge.

Keyphrases

copy number
induced apoptosis
cognitive decline
bone marrow
cell cycle arrest
acute myeloid leukemia
gene expression
dna methylation
immune response
cell proliferation
mild cognitive impairment
genome wide