Risk factors for Pseudomonas aeruginosa colonization in non-cystic fibrosis bronchiectasis and clinical implications.
Wang Chun KwokJames Chung Man HoTerence Chi Chun TamMary Sau Man IpDavid Chi Leung LamPublished in: Respiratory research (2021)
Pseudomonas aeruginosa colonization was more commonly found in patients with longer duration of bronchiectasis and those on proton pump inhibitors (PPIs) with adjusted ORs of 1.066 (95% CI = 1.036-1.096, p < 0.001) and 2.815 (95% CI = 1.307-6.064, p = 0.008) respectively. Patients with Pseudomonas aeruginosa colonization have more extensive lung involvement and higher risks of exacerbation requiring hospitalization with adjusted ORs of 2.445 (95% CI = 1.283-4.657, p = 0.007) and 2.745 (95% CI = 1.012-7.449, p = 0.047) respectively. Pseudomonas aeruginosa colonization is more common among patients with longer duration of bronchiectasis and those on PPI. Pseudomonas aeruginosa colonization is associated with more extensive lung involvement and higher risks of exacerbation requiring hospitalization.
Keyphrases
- cystic fibrosis
- pseudomonas aeruginosa
- biofilm formation
- lung function
- acinetobacter baumannii
- chronic obstructive pulmonary disease
- human health
- risk assessment
- intensive care unit
- air pollution
- escherichia coli
- candida albicans
- climate change
- small molecule
- drug resistant
- respiratory failure
- protein protein
- mechanical ventilation