GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance.

Kasper KatiskoAntti CajanusNadine HuberOlli JääskeläinenTarja KokkolaVirve KärkkäinenHannah RostalskiPaivi HartikainenAnne M KoivistoSanna HannonenJuha-Matti LehtolaVille E KorhonenSeppo HelisalmiHeli Koivumaa-HonkanenSanna-Kaisa HerukkaAnne M RemesEino SoljeAnnakaisa Haapasalo

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

sGFAP enabled differentiation of patients with FTLD and PPD and associated with shorter survival and more severe brain atrophy rate in patients with FTLD. These results suggest that blood-based GFAP represents a minimally invasive and useful biomarker in the differential diagnostics between patients with FTLD and PPD and in evaluating disease progression and astrogliosis in FTLD.

Keyphrases

minimally invasive
resting state
white matter
early onset
functional connectivity
robot assisted
brain injury