Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway.
Yuan-Yuan FangDongjie PengYuan LiangLi-Li LuJunyan LiLin ZhaoShi-Yan OuShaojun LiMichael AschnerYue-Ming JiangPublished in: Biological trace element research (2020)
Taken together, our results suggest that PAS-Na exerts anti-inflammatory effects in Mn-stimulated BV2 microglial cells via downregulation of NLRP3, CASP1, IL-1β, and I L-18. Furthermore, a high concentration and prolonged PAS-Na treatment appear necessary for its therapeutic efficacy. Taken together, we conclude that PAS-Na affords therapeutic efficacy in mitigating neurological conditions associated with neuroinflammation.
Keyphrases
- lipopolysaccharide induced
- lps induced
- induced apoptosis
- inflammatory response
- cell cycle arrest
- traumatic brain injury
- signaling pathway
- neuropathic pain
- endoplasmic reticulum stress
- cerebral ischemia
- cognitive impairment
- oxidative stress
- endothelial cells
- brain injury
- high glucose
- spinal cord injury
- combination therapy
- pi k akt
- drug induced