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Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma.

Kishor PantEstanislao PeixotoSeth RichardAalekhya BiswasM Gerard O'SullivanNasra GiamaYeonjung HaJun YinPietro CarotenutoMassimiliano SalatiYanan RenRendong YangBrunella FrancoLewis R RobertsSergio A Gradilone
Published in: Hepatology (Baltimore, Md.) (2021)
In conclusion, these results reveal the tumorigenic role of SIRT1 through modulation of primary cilia formation and provide the rationale for developing therapeutic approaches for CCA using SIRT1 as a target.
Keyphrases
  • histone deacetylase
  • oxidative stress
  • ischemia reperfusion injury
  • clinical trial
  • genome wide
  • single cell
  • gene expression
  • dna methylation