Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma.
Kishor PantEstanislao PeixotoSeth RichardAalekhya BiswasM Gerard O'SullivanNasra GiamaYeonjung HaJun YinPietro CarotenutoMassimiliano SalatiYanan RenRendong YangBrunella FrancoLewis R RobertsSergio A GradilonePublished in: Hepatology (Baltimore, Md.) (2021)
In conclusion, these results reveal the tumorigenic role of SIRT1 through modulation of primary cilia formation and provide the rationale for developing therapeutic approaches for CCA using SIRT1 as a target.