Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer.

Chunyan LiuYingying ZhengJunyi TangDawei WangZhenshen MaShutong LiXiaotian Chang

Published in: Journal of immunology research (2019)

This study demonstrates that stimulation of DC-CIK cells with PADI4 significantly suppressed tumor growth in tumor-bearing mice by promoting DC maturation, CIK cell proliferation, and cytotoxicity. PADI4 may be a potential tumor marker that could be used to improve the therapeutic efficiency of DC-CIK cells.

Keyphrases

induced apoptosis
dendritic cells
cell proliferation
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death
metabolic syndrome
cell cycle
signaling pathway
adipose tissue
pi k akt
risk assessment