Empagliflozin inhibits excessive autophagy through the AMPK/GSK3β signaling pathway in diabetic cardiomyopathy.

Rosalinda MadonnaStefania MoscatoMaria Concetta CufaroDamiana PieragostinoLetizia MattiiPiero Del BoccioSandra GhelardoniRiccardo ZucchiRaffaele De Caterina

Published in: Cardiovascular research (2023)

Taken together, our results describe a novel paradigm in which EMPA inhibits hyperactivation of autophagy through the AMPK/GSK3β signaling pathway in the context of diabetes.

Keyphrases

signaling pathway
pi k akt
type diabetes
induced apoptosis
epithelial mesenchymal transition
skeletal muscle
heart failure
cell death
protein kinase
glycemic control
endoplasmic reticulum stress
weight gain
oxidative stress
insulin resistance
physical activity
atrial fibrillation
adipose tissue