Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment.

T Leigh Spencer NoakesThomas S PrzybycienAmanda ForwellConnor NichollsYu-Qing ZhouDarci T ButcherRosanna WeksbergSharon L GugerBrenda J SpieglerRussell J SchacharJohann HitzlerShinya ItoEllen van der PlasBrian J Nieman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Multiple ALL chemotherapy agents can affect postnatal brain development or heart function. This study provides a ranking of agents based on potential toxicity, and thus highlights a subset likely to cause side effects in early adulthood for further study.

Keyphrases

mouse model
heart failure
white matter
atrial fibrillation
oxidative stress
acute myeloid leukemia
depressive symptoms
locally advanced
squamous cell carcinoma
resting state
radiation therapy
early life
risk assessment
blood brain barrier