A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues.

Longwei HeXueling YangKaixin XuWeiying Lin

Published in: Chemical communications (Cambridge, England) (2018)

The mitochondria-targeted turn-on fluorescent probe (Mito-FMP) based on a benzoxadiazole platform was developed for detection of malondialdehyde (MDA). Mito-FMP performed with large enhancement of the optical signal (774-fold) in response to MDA in an aqueous system and has the capability of monitoring endogenous MDA in HeLa cells and onion tissues.

Keyphrases

fluorescent probe
cell cycle arrest
cell death
living cells
pi k akt
induced apoptosis
high resolution
breast cancer cells
gene expression
cancer therapy
signaling pathway
reactive oxygen species
oxidative stress
ionic liquid
photodynamic therapy
real time pcr