Effect of testosterone therapy on breast tissue composition and mammographic breast density in trans masculine individuals.
Yujing J HengGabrielle M BakerValerie J Fein-ZacharyYaileen D Guzman-ArochoVanessa C Bret-MounetErica S MassicottSy GitinPaul RussoAdam M TobiasRichard A BartlettGopal VarmaDespina KontosLusine YaghjyanMichael S IrwigJennifer E PotterGerburg M WulfPublished in: medRxiv : the preprint server for health sciences (2024)
Very little is known about the effect of gender-affirming testosterone therapy on cancer risks, such as breast cancer.Epidemiological studies had different conclusions about the association between testosterone and breast cancer in cisgender women (positive association) and trans masculine individuals (inverse association).More laboratory-based research are needed to understand the effect of testosterone on breast cancer risk in the understudied trans masculine population.Our study provides quantitative histological evidence to support prior epidemiological reports that testosterone may reduce breast cancer risk in trans masculine individuals.