Inflammation-Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double-Stranded RNA-Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma.
Jie DingJingjing ZhaoLin HuanYizhe LiuYejun QiaoZhen WangZhiao ChenShenglin HuangYingjun ZhaoXiang-Huo HePublished in: Hepatology (Baltimore, Md.) (2020)
Our findings indicate that LINC00665 is involved in the NF-κB signaling activation in HCC cells and that the inflammatory LINC00665/PKR/NF-κB loop plays important oncogenic roles in hepatic cancer progression and may be a potential therapeutic target.
Keyphrases
- nuclear factor
- long non coding rna
- long noncoding rna
- toll like receptor
- cell proliferation
- oxidative stress
- induced apoptosis
- signaling pathway
- protein kinase
- diabetic rats
- nucleic acid
- transcription factor
- papillary thyroid
- cell cycle arrest
- high glucose
- squamous cell
- pi k akt
- endoplasmic reticulum stress
- drug induced
- squamous cell carcinoma
- human health
- lps induced
- risk assessment
- lymph node metastasis
- stress induced