A single priming event prevents oral tolerance to peanut.
Johanna M SmeekensRobert M ImmorminoJanelle R KesselringAndrew V TurnerMichael D KulisTimothy P MoranPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2023)
A single airway exposure to peanut plus adjuvant is sufficient to prime the immune system to develop allergy following subsequent high-dose oral exposure. These results highlight the importance of introducing peanut as early as possible to prevent sensitization through a non-oral priming event.