An injectable hydrogel dressing for controlled release of hydrogen sulfide pleiotropically mediates the wound microenvironment.
Junwei YangXianzhen DongWenying WeiKun LiuXiaopei WuHongLian DaiPublished in: Journal of materials chemistry. B (2024)
The healing of scalded wounds faces many challenges such as chronic inflammation, oxidative stress, wound infection, and difficulties in vascular and nerve regeneration. Treating a single problem cannot effectively coordinate the complex regenerative microenvironment of scalded wounds, limiting the healing and functional recovery of the skin. Therefore, there is a need to develop a multi-effect treatment plan that can adaptively address the issues at each stage of wound healing. In this study, we propose a scheme for on-demand release of hydrogen sulfide (H 2 S) based on the concentration of reactive oxygen species (ROS) in the wound microenvironment. This is achieved by encapsulating peroxythiocarbamate (PTCM) in the ROS-responsive polymer poly(ethylene glycol)-poly(L-methionine) (PMet) to form nanoparticles, which are loaded into a thermosensitive injectable hydrogel, F127-poly(L-aspartic acid- N -hydroxysuccinimide) (F127-P(Asp-NHS)), to create a scald dressing. The H 2 S released by the hydrogel dressing on demand regulates the wound microenvironment by alleviating infection, reducing oxidative stress, and remodeling inflammation, thereby accelerating the healing of full-thickness scalded wounds. This hydrogel dressing for the adaptive release of H 2 S has great potential in addressing complex scalded wounds associated with infection and chronic inflammation.
Keyphrases
- wound healing
- oxidative stress
- stem cells
- reactive oxygen species
- dna damage
- diabetic rats
- ischemia reperfusion injury
- induced apoptosis
- tissue engineering
- cell death
- hyaluronic acid
- mesenchymal stem cells
- drug delivery
- cell therapy
- patient safety
- amino acid
- risk assessment
- signaling pathway
- endoplasmic reticulum stress